Cognitive-behavioral therapy has side effects. But unlike drugs, they're good.

When I started CBT, my only goal was to stop having panic attacks. What I didn't expect was that the treatment would come with side effects. All positive.

· 4 min read

Cognitive-behavioral therapy has side effects. But unlike drugs, they're good.

When I started cognitive-behavioral therapy, my only goal was to stop having panic attacks. Nothing more. To recover something resembling the life I had before — being able to get on a bike, go outside without checking my pulse every two minutes, not feeling trapped in my own apartment. The bar wasn't especially high.

What I didn't expect was that the treatment would come with side effects.


CBT for panic and anxiety works through a very specific mechanism: fear extinction. During periods of avoidance, the brain generates what is known as fear memory, a pattern of neural connections that converts mundane situations into threat signals. The treatment seeks to rewrite those connections through repeated exposure, showing the nervous system that the alarm was false. This is not a metaphor: it is measurable neuroplasticity, structural changes in the medial prefrontal cortex that regulate the response of the limbic system [3][6].

The evidence for its effectiveness is solid and consistent. A meta-analysis published in JAMA Psychiatry reviewing the long-term outcomes of CBT for anxiety disorders found significant improvements that persisted years after treatment [1]. For panic disorder in particular, studies show response rates superior to any other available therapeutic approach [2].

But here something appears that studies mention less frequently than the main efficacy data.


People who successfully complete exposure therapy don't just stop having panic. They develop something psychology calls self-efficacy: confidence in one's own ability to face difficult situations. And that confidence, built exposure by exposure, doesn't stay encapsulated in the context of anxiety. It generalises.

The research on this is consistent. Goldin and colleagues demonstrated that emotional regulation self-efficacy acts as a mediator of CBT outcomes: you don't improve only because fear diminishes, but because you convince yourself, with accumulated evidence, that you are capable of managing it [7]. Maddux and Meier documented how this state becomes a stable trait that shapes the way a person faces the rest of the challenges in their life, not just those related to anxiety [8].

Put more directly: someone who goes through the complete process of repeatedly exposing themselves to their most intense fears ends up being, statistically, more capable of facing adversity in general. Anxiety was the hardest school you can imagine, and the certificate it issues is not just the absence of panic.


There is one important detail worth not losing sight of: anxiety and fear do not disappear after treatment, nor should they. They are functional, necessary evolutionary responses that form part of any healthy nervous system [5]. What is extinguished is the overreaction — the triggering of the alarm in response to signals that don't represent real threat. The goal is not a fearless brain. It is a brain that calibrates better.

That distinction matters because it changes the way recovery can be understood. It is not about going back to who you were before. It is about building something different on the same ground.


I have been walking the Morgenrot Trail for more than five years. In all that time I have accumulated enough failed exposures, relapses, and also small victories to have a formed opinion on this. The self-efficacy that the literature describes is not an abstract promise. It is something that is built so slowly you don't see it happening, and that one day you suddenly recognise in the way you react to a situation that would once have paralysed you.

Not because the fear isn't there. But because you already know you can walk through it.


References

[1] Dis EAM van, Veen SC van, Hagenaars MA, et al. Long-term Outcomes of Cognitive Behavioral Therapy for Anxiety-Related Disorders: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2020;77(3):265–273.

[2] Papola D, Ostuzzi G, Tedeschi F, et al. CBT treatment delivery formats for panic disorder: A systematic review and network meta-analysis of randomised controlled trials. Psychological Medicine. 2023;53(3):614–624.

[3] Reinecke A, Waldenmaier L, Cooper MJ, Harmer CJ. Changes in Automatic Threat Processing Precede and Predict Clinical Changes with Exposure-Based Cognitive-Behavior Therapy for Panic Disorder. Biological Psychiatry. 2013;73(11):1064–1070.

[5] Nesse RM. Anxiety Disorders in Evolutionary Perspective. In: Abed RT, St John-Smith P, eds. Evolutionary Psychiatry: Current Perspectives on Evolution and Mental Health. Cambridge University Press; 2022:101–116.

[6] Giustino TF, Maren S. The role of the medial prefrontal cortex in the conditioning and extinction of fear. Frontiers in Behavioral Neuroscience. 2015;9:298.

[7] Goldin PR, Ziv M, Jazaieri H, et al. Cognitive reappraisal self-efficacy mediates the effects of individual cognitive-behavioral therapy for social anxiety disorder. Journal of Consulting and Clinical Psychology. 2012;80(6):1034–1040.

[8] Maddux JE, Meier LJ. Self-Efficacy: A Foundational Concept for Positive Clinical Psychology. In: Snyder CR, Lopez SJ, eds. The Wiley Handbook of Positive Clinical Psychology. Wiley; 2015:89–101.

Back to Blog